The process of energy generation by mitochondria is closely tied to intracellular calcium regulation by a membrane gateway inside mitochondria known as the mitochondrial Ca2+ uniporter (MCU). How MCU ...

The transport activity of human mitochondrial aspartate/glutamate carriers is central to the malate–aspartate shuttle, urea cycle, gluconeogenesis and myelin synthesis. They have a unique three-domain ...

The calcium-sensing receptor (CSR) is a G-protein receptor that plays a critical role in calcium regulation. In the kidney, the CSR regulates calcium reabsorption in the thick ascending limb, where ...

Neutralizing these regions completely abolished calcium regulation, and the mitochondria became overloaded with calcium. From this, the team found that EMRE-dependent matrix calcium regulation of MCU ...

You've heard that calcium protects your bones and that your glass of milk is loaded with it, but what do you really know about this essential nutrient? Most people may not realize that calcium is the ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...

Milk has some competition when it comes to calcium.